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Postdoctoral position : Pathophysiology of epilepsy - ICM

Soumis par admin le mar, 03/15/2016 - 14:50

Postdoctoral position : Pathophysiology of epilepsy- in vivo microelectrodes recordings

Institut du Cerveau et de la Moelle Epinière, Paris, France

The « EpiMicro » group, within the Pr Stephane Charpier’s team, at the Brain and Spine Institute (ICM) in Paris, is looking for a postdoctoral fellow to participate in a project on intracerebral recordings with macro and microelectrodes in epileptic patients. The ICM is a newly created institute focusing on basic and translational research in neuroscience and is located in the heart of Paris within the largest European hospital.

The general goal of this project is to improve knowledge on pathophysiology of epilepsy, in particular the interictal events and the epileptic seizures. With the development of intracerebral recordings with microelectrodes for many years in our epileptic patients, we are now able to perform intracerebral recordings at different scales, from usual macroelectrodes to unique neuron recordings, in the interictal period but also during seizures, in multiple intracerebral areas.

The primary role of the position will be to perform electrophysiological analysis of intracerebral datas at different periods: during the interictal period and preictal period and to study the link with multiunit activities in cortical areas. The project will concern human partial epilepsy and also animal models of epilepsy.  We are currently studying the dynamics of seizure emergence in different models of mice and rat. 

The doc /post-doc will be integrated in a multidisciplinary team including researchers, engineers, clinical electrophysiologists, neuroradiologists and neurosurgeons.  He/she will receive assistance for an engineer for the data acquisition and storage. In addition, he/she will have inputs from several researchers in methods of signal analysis.

The postdoctoral fellow will have responsibilities for data analysis and preparation of scientific publications.

The candidate should have a PhD or equivalent in Signal analysis or Neuroscience related field. Expertise in signal processing and good analytical skills (MATLAB) are required. Since the analytic approaches needed for this study have been extensively developed and used in animals, experience in animal in vivo or in vitro experiments is a plus.

The starting date is April 2016. The proposition is for an initial period of 24 months with possible renewal (total of 3 years). The competitive salary will be according to experience. The candidate will also have access to the French system benefits.

Keywords : intracerebral recordings, microelectrodes, epileptic patients

Thanks for forwarding a CV, a cover letter and names of 2 references to :

Pr Vincent Navarro

vincent.navarro@aphp.fr